This study addresses a neglected area in men's health. This study provides service for both HPV testing and treatment of anal abnormalities that are rarely available elsewhere. If the results of this study fin that treating high-risk anal abnormalities is effective at reducing risk for cancer, we expect a shift in how medical providers care for their patients in regards to anal cancer screening. As anal cancer disproportionately affects people living with HIV, every person who participates in this study have an impact on the health and longevity for others living with HIV. There are many reasons why you may feel good about your participation, and we appreciate your participation in every case.